10.25 - Sabban - RNA Processing

10.25 - Sabban - RNA Processing - trailer sequences, modied...

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RNA Processing 1 Dr. Sabban 10/25/2007 2 3 RNAs in E.coli Type Function # of Different Kinds # of Nucleotides % of RNA Synthesis % of Total RNA in cell Stability mRNA messenger Thousands 500-6,000 40-50 3 Unstable (t 1/2 =1-3 min) rRNA Structure and Function of ribosomes Three: 23S, 16S, 5S 2,800 1,540 120 50 90 Stable tRNA Adapter 50-60 75-90 3 7 Stable RNA Primers DNA replication ? < 50 < 1 < 1 Unstable RNA Component of RNaseP Catalytic 1 377 < 1 < 1 ?
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4 5 6
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Coding strand also known as sense or (+) strand Template strand also known as antisense or (-) strand 7 Prokaryotes Eukaryotes mRNA No processing Capping at 5 end Splicing , Poly (A) addition at 3 end (RNA editing) tRNA Removal of leader and
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Unformatted text preview: trailer sequences, modied bases Removal of leader and trailer sequences, modied bases rRNA Many endo- and exonuclease cleavages 4S 4S Many endo- and exonuclease cleavages 16S, 4S, 23S, 5S 18S, 5.8S, 28S 8 9 10 Modifications assisted by snoRNPs (small nucleolar ribonucleoproteins) Eukaryotic RNA Polymerase I Transcript 11 12 13 14 15 16 Processing of Eukaryotic mRNAs 17 Cap structure on 5 end of eukaryotic mRNAs 18 19 RNA Editing 20 GU. .AG Rule 21 Splicing of Introns 22 23 24 25 26 27 28 29 30 31 32 33 34 Alternative Splicing 35 36 37 38 39 40...
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This note was uploaded on 04/18/2008 for the course BIOC 1010 taught by Professor Zhang during the Fall '07 term at New York Medical College.

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10.25 - Sabban - RNA Processing - trailer sequences, modied...

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