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Unformatted text preview: Transcription Biosynthesis of RNA Dr. Sabban 10/23/2007 1 DNA RNA Polypeptide Functional protein Transcription Translation Folding Template (antisense) strand Coding (sense) strand 2 Major classes of RNA Prokaryotes rRNA: 16S, 23S, 5S (80% of cellular RNA); stable tRNA: 4S (15% of cellular RNA); stable mRNA: heterogeneous (5% of cellular RNA); rapid turnover Eukaryotes rRNA: 18S, 28S, 5S, 5.8S (80% of cellular RNA); stable tRNA: 4S (15% of cellular RNA); stable mRNA: heterogeneous (2-5% of cellular RNA); rapid turnover 3 snRNA: Low M.W. nucleus located RNAs involved in splicing; rich in U s RNA component of SRP Micro RNA (miRNA) small (about 21 nucleotides) non coding RNA complementary to mRNA and inhibit translation Small interfering RNA (siRNA) small RNAs that bind mRNA and facilitate its degradation RNA component of telemerase Additional Small RNAs in Eukaryotes 4 RNA polymerase will read the top (template, antisense -) strand 3...
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- Fall '07