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Unformatted text preview: Transcription Biosynthesis of RNA Dr. Sabban 10/23/2007 1 DNA RNA Polypeptide Functional protein Transcription Translation Folding Template (antisense) strand Coding (sense) strand 2 Major classes of RNA Prokaryotes • rRNA: 16S, 23S, 5S (80% of cellular RNA); stable • tRNA: 4S (15% of cellular RNA); stable • mRNA: heterogeneous (5% of cellular RNA); rapid turnover Eukaryotes • rRNA: 18S, 28S, 5S, 5.8S (80% of cellular RNA); stable • tRNA: 4S (15% of cellular RNA); stable • mRNA: heterogeneous (2-5% of cellular RNA); rapid turnover 3 • snRNA: Low M.W. nucleus located RNAs involved in splicing; rich in U ’ s • RNA component of SRP • Micro RNA (miRNA) small (about 21 nucleotides) non coding RNA complementary to mRNA and inhibit translation • Small interfering RNA (siRNA) small RNAs that bind mRNA and facilitate its degradation • RNA component of telemerase Additional Small RNAs in Eukaryotes 4 RNA polymerase will read the top (template, antisense -) strand 3 ’ →...
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This note was uploaded on 04/18/2008 for the course BIOC 1010 taught by Professor Zhang during the Fall '07 term at New York Medical College.
- Fall '07