12.11 - Olson - Cell Signaling

12.11 - Olson - Cell Signaling - (nuclear localization...

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1 Heterotrimeric G Protein Signalling GEP GAP 2 Ras, Monomeric GTPase 3 G Protein Coupled Receptors
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www.mnstate.edu 4 5 Families of GPCR Ligands 6 Families of Heterotrimeric GTP Binding Proteins
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Cholera toxin Pertussis toxin 7 Adenylate Cyclase 8 Cholera Toxin 9 Mechanism of PKA Activation
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10 βγ-Directed GPCR Phosphorylation 11 Phosphoinositide Cycle (PLC) 12 Phosphoinositide Cycle (PLC)
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13 14 Activation of Protein Kinase C 15 Activation of Calcium/Calmodulin Kinase
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16 Calmodulin 17 Taste (Gustducin) Olfactory System 18
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19 Formation of Second Messengers 20 Visual System 21 Visual System
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22 Visual System 23 24
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25 Insulin Activation of MAPK Cascade 26 Insulin Stimulation of Glycogen Synthesis
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Unformatted text preview: (nuclear localization sequence) 27 Cytokine Activation of JAK/STAT Pathway 28 Interferon activation of JAK/STAT Pathway 29 Cytokine Stimulates Phosphorylation and Nuclear Retention of STATs 30 While non-phosphorylated STAT proteins constantly shuttle between the cytoplasm and nucleus, the phosphorylated STAT protein is retained in the nucleus and is only released upon dephosphorylation by nuclear phosphatases. 18,19 Therefore, nuclear retention, not translocation, of the active phosphorylated STAT protein is the important feature of cytokine-induced STAT activation....
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  • Fall '07
  • Zhang
  • Protein kinase C, phosphorylated STAT protein, cytokine-induced STAT activation, GPCR Ligands, Nuclear Retention

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12.11 - Olson - Cell Signaling - (nuclear localization...

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