2. Sabban - Fatty Acid Oxidation and Ketogenesis

2. Sabban - Fatty Acid Oxidation and Ketogenesis -...

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Unformatted text preview: Catabolism of Triglycerides 1 Glycerol can enter glycolytic pathway in liver 2 -Oxidation Degradation of Fatty Acids in Mitochondria 3 Acyl CoA Synthetase (Thiokinase) 2-high energy bonds Activation - Charging of Fatty Acid 4 Entry of Fatty Acids into Mitochondria 5 Site of fatty acid attachment CARNITINE 6 7 8 Steps of -Oxidation 9 Group of enzymes depending on length of fatty acid SCAC (C4-C6) MCAD (C8-C12) LCAD (>C12) Fatty Acyl CoA Dehydrogenase 10 Enoyl CoA Hydratase 11 -hydroxyacyl CoA dehydrogenase 12 Thiolase 13 14 Each step length of FA decreased by 2 carbons 15 16 One less FADH 2 generated -oxidation of unsaturated fatty acid with single double bond 17 -oxidation of unsaturated fatty acid with two double bonds 18 -oxidation of odd numbered fatty acids leads to propionyl CoA 19 No net synthesis of glucose from even numbered fatty acids Propionyl CoA is only glucogenic part in fatty acid metabolism 20 Formation of Ketone Bodies Soluble form of energy form fatty acids 21 Formation of Ketone Bodies 22 23...
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2. Sabban - Fatty Acid Oxidation and Ketogenesis -...

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