1. Sabban - Lipid Digestion and Absorption

1. Sabban - Lipid Digestion and Absorption - Lipid Defined...

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Unformatted text preview: Lipid Defined operationally as those substances from living organisms that dissolve in nonpolar solvents such as ether, chloroform and acetone but not appreciably in water. 1 IMPORTANCE OF LIPIDS STRUCTURE Comprise lipid bilayer in biological membranes METABOLISM Storage of metabolic fuel Transport of metabolic fuel SIGNALLING MOLECULES Intracellular signalling-generation of second messengers Inter-cellular signalling TARGETTING eg, covalent modif of proteins 2 Saturated and Unsaturated Fatty Acids 3 Digestion and Absorption of Lipids 4 Structure of a Triglyceride 5 6 7 Pancreatic Lipase (in small intestine) Triglyceride to beta-monoglyceride and two fatty acids 8 9 Lipoproteins In cylomicrons: Apo A-1, ApoA-II and IV and ApoB-48 made in intestine. Apo C-II and Apo E acquired from plamsa HDL 10 11 Before meal After meal 12 Lipoprotein Lipase Triglyceride to glycerol and 3 fatty acids 13 dietary fat lipoprotein lipase fatty acids Lipolysis Triglycerides Phospholipids Cholesterol esters Monoglycerides Free fatty acids Cholesterol lymphatics chylomicrons chylomicron remnant liver 14 15 Mobilization of Fats from Adipose Cells 16 17 18 19 20 ...
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This note was uploaded on 04/18/2008 for the course BIOC 1010 taught by Professor Zhang during the Fall '07 term at New York Medical College.

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1. Sabban - Lipid Digestion and Absorption - Lipid Defined...

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