01.15 - Wu - Intro to Metabolism

01.15 - Wu - Intro to Metabolism - Introduction to...

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Unformatted text preview: Introduction to Metabolism Dr. Joseph M. Wu January 15, 2008 1 Overview of Cellular Activities Macromolecular reactions require energy DNA synthesis: dNTPs RNA synthesis: NTPs Protein synthesis: ATP and GTP Energy required for orderliness of biological systems (thermodynamics) 2 Overview of Cellular Activities Proteins are drivers of biological systems Proteins as catalysts Proteins as structural elements Proteins as regulatory elements 3 Sources of energy Lipid fatty acids acetyl CoA CHO monosaccharides acetyl CoA Proteins Amino acids TCA cycle intermediates acetyl CoA Forward reaction are catabolic (energy yielding) Backward reactions are anabolic (energy demanding 4 Formation of building blocks from large precursors - I Conversion of building blocks to common end products - II TCA cycle and oxidative phosphorylation yields: Water Ammonia Carbon dioxide - III 5 Large small units Small units few common metabolites TCA + Ox. Phos. ATP + CO 2 Berg: Fig. 15.12 Important slide Source of energy 6 Adenylate energy charge Guanylate energy charge Berg: Fig. 15.19 Important slide 7 Evaluation of energy status...
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This note was uploaded on 04/18/2008 for the course BIOC 1010 taught by Professor Zhang during the Fall '07 term at New York Medical College.

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01.15 - Wu - Intro to Metabolism - Introduction to...

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