04.09 - Leonard - Motor Systems II

04.09 - Leonard - Motor Systems II - Coding of movment by...

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Unformatted text preview: Coding of movment by corticospinal neurons 1. firing begins before onset of movement 2. amount of firing is related to required force (not displacement) 3. neurons fire most for movments in a particular direction (broadly tuned) 4. different neurons prefer different directions of movements Thus, corticospinal neurons fire in relation to the force necessary to support a movement trajectory 1 2 Coding of mevement direction by motor cortex neurons 3 Representation of learned movement expands with skill in primary motor cortex 4 These data suggest: 1. Brief, daily training epochs initiate "slow" processes that result large performance changes that occur over a few weeks 2. Acquisition and retention of motor skills results in significant reorganization in movement representation within primary motor cortex of the adult human brain 5 6 7 8 Cerebellum is Topographically Organized into Parasagital Zones 9 10 11 12 13 14 15 Parkinson's Disease Debilitating progressive loss of motor function 500K cases in the US. Commonly found in >55 YOs Symptoms Akinesia Rigidity Bradykinesia Resting tremor. (pill-rolling) Flexed posture and shuffling gait General paucity of movement Reptillian stare Hallmark pathology: loss of Dopamine synthesizing neurons in the Substantia Nigra Treatment with precursor L-DOPA; Also given Carbidopa to inhibit peripheral DA synthesis MPTP 16 17 Normal Cerebellar disease Parkinson's disease 18 ...
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04.09 - Leonard - Motor Systems II - Coding of movment by...

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