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1What Happens in The Body: Cushing’s Disease?Hannah BugbeeGalen College of NursingBIO 1300 Human Anatomy & Physiology IIDr. ZafirMarch 6, 2022
2The Pathology Behind Cushing DiseaseCushing's Disease is a condition that involves increased levels of cortisol secretion by theadrenal cortex—based on corticosteroids' external administration, leading to a hypercortisolismcondition known as Cushing's Disease (Tiruneh et al., 2017). The pituitary gland is found tooversecrete Adrenocorticotropic hormone (ACTH), leading to hypercortisolism or, in otherwords, Cushing's Disease. Which in humans occurs when glucocorticoids are high in the body.Various factors could lead to increased glucocorticoid levels. One is when the internal cortisol isoverproduced in the adrenal cortex (Newell-Price et al., 2006). Another leading factor is theincrease of external pharmacological synthetic glucocorticoid administration. Neoplasms lead toan overproduction of endogenous glucocorticoid, causing a direct secretion of proteins andcortisol. Found in most cases, this usually leads to regulating the secretion of adrenocorticalcortisol. Most found of the people who are diagnosed with Cushing's Disease have been found tohave one thing in common. Corticosteroid medications are commonly used in treatment plans ofdiseases and conditions such as asthma, multiple sclerosis, and rheumatoid arthritis (Tiruneh etal., 2017). However, hypercortisolism is not a common condition, and its existence in the entireworld is slim to none. It combines every cause of the Disease. It sums up to thirteen cases forevery one million people, with an overall estimation of only two new cases of this condition peryear (Tiruneh et al., 2017).Normality In Major Body SystemsThe pituitary gland is the part that majorly leads to the condition. The pituitary gland isfound in the brain and is a major endocrine system gland known as the hypophysis. Which isresponsible for the secretion of hormones that help function the actions of other organs in theendocrine system and various tissues around the body. The pituitary gland has the shape of a pea,and it is located on the underside of the brain, where it suspends with the support of the pituitary
3stalk (Newell-Price et al., 2006). The pituitary is anatomically a two-in-one structure thatconsists of the posterior pituitary and the anterior pituitary, with all the parts that function

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Term
Summer
Professor
Dr. Rios
Tags
Cortisol, Cushing

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