Acromegaly: History of pathology: Acromegaly is a hormonal disorder commonly occurs in adults. It is a too much growth hormone (GH) of pituitary gland in the body. The most common factor of Acromegaly is a GH secreting pituitary adenoma. In this disease, the body bones increase in size such as hands, feet and face. It is slowly progressed disease occurs in adults in their age of 40’s and s0’s. If it’s untreated then it can lead to death including the problems with heart disease, secondary hypertension, diabetes mellitus, and malignancy. If these condition occurs in children called gigantism. The skeletal bones would growth and the children height would be increases abnormally. Pierre Marie first discovered Acromegaly as a medical syndrome in 1886. The cause was not sure of pituitary gland until 1900 when Benda and other researcher suggested that the cause of Acromegaly would be the hypertrophy or hyperplasia of the pituitary gland. Causes: Acromegaly is caused by overproduction of pituitary gland hormone growth hormone which secretes into bloodstream that stimulates liver and produce another hormone called insulin like growth factor 1 (IGF-1). IGF 1 stimulates tissue growth and bone growth in the body. Excessive amount of IGF-1 signals the pituitary to reduce GH production. Sign and symptoms of Acromegaly: enlarged hands and feet facial features become coarse and enlarged as bones grow body hair becomes coarse as the skin thickens and/or darkens increased perspiration accompanied with body odor protruding jaw voice deepening enlarged lip, nose, and tongue thickened ribs (creating a barrel chest), joint pain
degenerative arthritis enlarged heart, kidney, spleen and other organs fatigue and weakness snoring, headaches impaired vision abnormalities in menstrual cycles in women and breast discharge in women impotence in men Epidemiology: The disease is rare and affects both men and women. The average age of the disease is about age of 40 to 50 years. There are 40 to 60 cases per million and increases 3 to 4 new cases in a year. In the USA, there are roughly 15,000 to 27,000 patients are diagnosed with Acromegaly. It is occur 4 to 10 years after onset of Growth
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- Spring '08
- Pathology, Acromegaly