BIO 110 Module 3 Homework Assignments (22 pts.) Sam Brooks Exercises 1-4 can be found on this University of Utah site : (opens in a new window Ex. 1 Personalized Medicine (3 pts.) Under Human Health click on Pharmacogenomics , then Your Doctor’s New Genetic Tools Answer the following questions as you go through the animation: 1. Explain the concept of pharmacogenomics. Is the study of how genes affect a person’s response to drugs. Involves pharmacology and genomics to create effective and safe medications and doses that can be tailored to a person’s genetic makeup. 2. Purinethol has been used to treat leukemia for over 30 years. Using at least two sentences, explain why this chemotherapeutic drug worked well in some people but caused serious side effects or even death in others. People vary in their TPMT enzyme activity level. This TPMT enzyme is responsible for breaking down and inactivating the drug Purinethol. It is important to know what a patients TPMT level is because Purinethol is a toxic substance and only needs to remain in the body for a limited amount of time to break down cancer cells. If patients are unable to break down Purinethol they will suffer toxic side effects. 3. a) Name one advantage of using drug treatment that is based upon one’s specific genetic variation. Doctors can choose the right for a specific patient and can determine a patient’s risk for getting a particular disease and design a prevention strategy for that disease. Doctors can also make accurate diagnosis and avoid the patient enduring harmful side effects. b) Name one possible disadvantage of this type of treatment (you’ll have to think about this). One could be that private DNA results could become used for the public in treating other people.