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Running head: SYSTEMATIC RESEARCH REVIEW LEVETIRACETAM1Critique of a Systematic Research Review: Levetiracetam for neuropathic pain in adultsBrenda MabryChamberlain College of NursingNR 505: Advanced Research Methods: Evidence-Based PracticeFebruary 2016
CRITIQUE OF SYSTEMATIC RESEARCH REVIEW2Critique of Systematic Research Review: Levetiracetam for neuropathic pain in adultsChronic pain is something that afflicts between 20%-25% of people around the world every day (Fornasari, 2014). Pain is “an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage" (as cited in Fornasari, 2014, p. 165). There are different categories of pain including duration, type, site, andetiology (Rodriguez, 2015). Neuropathic pain, a type of chronic pain where there is damage or change to the modulation phase of types of pain (Rodriguez, 2015), is “pain caused by a lesion or disease” (as cited in Wiffen, Derry, Moore, & Lunn, 2014) of one of the five senses like taste, hearing smell. Nociceptive, or pain awareness impulses are conducted throughout the spinal cord(Rodriguez, 2015). Serotonin, endogenous opioids, and norepinephrine are then dispersed by the spinal cord to reduce the feeling of pain (Rodriguez, 2015). It is possible to have neuropathic pain occur anywhere in the nervous system (Taverner, 2014). When there is a breakdown in pain relief such as in severed nerve endings from an amputation of a limb, neuropathic pain occurs. Attempting to control neuropathic pain successfully can be challenging. Neuropathic pain controloften requires multiple interventions from different healthcare specialties. Even then, narcotic use may still not be sufficient. Other pharmacological treatments that have been utilized are antidepressant and antiepileptic medications. One of the first places patients go for pain control is primary care. It is important for the family nurse practitioner to be pharmacologically aware ofwhat medications are appropriate for neuropathic pain management. Wiffen, Derry, Moore, and Lunn (2014) conducted a systematic research review (SRR) toestablish whether levetiracetam was useful for treating neuropathic pain. Previously, other antiepileptic medications like gabapentin have been used to treat neuropathic pain effectively
CRITIQUE OF SYSTEMATIC RESEARCH REVIEW3(Wiffen, Derry, Moore, & Lunn, (2014). The purpose of the review was to evaluate how effectively levetiracetam was to treat neuropathic pain.Critique the research rigor of the studies used in the SRRWiffen, Derry, Moore, and Lunn (2014) sought to establish the effectiveness of levetiracetam for neuropathic pain in adults. Since levetiracetam is not a common medication prescribed for neuropathic pain nor is it approved for treating neuropathic pain, Wiffen, Derry, Moore, and Lunn wanted to search for and investigate the possible improvements a patient with neuropathic pain might have when taking levetiracetam. The intention of the authors was also to