Critique of Systematic Research Review - Running head SYSTEMATIC RESEARCH REVIEW LEVETIRACETAM Critique of a Systematic Research Review Levetiracetam

Critique of Systematic Research Review - Running head...

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Running head: SYSTEMATIC RESEARCH REVIEW LEVETIRACETAM 1 Critique of a Systematic Research Review: Levetiracetam for neuropathic pain in adults Brenda Mabry Chamberlain College of Nursing NR 505: Advanced Research Methods: Evidence-Based Practice February 2016
CRITIQUE OF SYSTEMATIC RESEARCH REVIEW 2 Critique of Systematic Research Review: Levetiracetam for neuropathic pain in adults Chronic pain is something that afflicts between 20%-25% of people around the world every day (Fornasari, 2014). Pain is “an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage" (as cited in Fornasari, 2014, p. 165). There are different categories of pain including duration, type, site, and etiology (Rodriguez, 2015). Neuropathic pain, a type of chronic pain where there is damage or change to the modulation phase of types of pain (Rodriguez, 2015), is “pain caused by a lesion or disease” (as cited in Wiffen, Derry, Moore, & Lunn, 2014) of one of the five senses like taste, hearing smell. Nociceptive, or pain awareness impulses are conducted throughout the spinal cord (Rodriguez, 2015). Serotonin, endogenous opioids, and norepinephrine are then dispersed by the spinal cord to reduce the feeling of pain (Rodriguez, 2015). It is possible to have neuropathic pain occur anywhere in the nervous system (Taverner, 2014). When there is a breakdown in pain relief such as in severed nerve endings from an amputation of a limb, neuropathic pain occurs. Attempting to control neuropathic pain successfully can be challenging. Neuropathic pain control often requires multiple interventions from different healthcare specialties. Even then, narcotic use may still not be sufficient. Other pharmacological treatments that have been utilized are antidepressant and antiepileptic medications. One of the first places patients go for pain control is primary care. It is important for the family nurse practitioner to be pharmacologically aware of what medications are appropriate for neuropathic pain management. Wiffen, Derry, Moore, and Lunn (2014) conducted a systematic research review (SRR) to establish whether levetiracetam was useful for treating neuropathic pain. Previously, other antiepileptic medications like gabapentin have been used to treat neuropathic pain effectively
CRITIQUE OF SYSTEMATIC RESEARCH REVIEW 3 (Wiffen, Derry, Moore, & Lunn, (2014). The purpose of the review was to evaluate how effectively levetiracetam was to treat neuropathic pain. Critique the research rigor of the studies used in the SRR Wiffen, Derry, Moore, and Lunn (2014) sought to establish the effectiveness of levetiracetam for neuropathic pain in adults. Since levetiracetam is not a common medication prescribed for neuropathic pain nor is it approved for treating neuropathic pain, Wiffen, Derry, Moore, and Lunn wanted to search for and investigate the possible improvements a patient with neuropathic pain might have when taking levetiracetam. The intention of the authors was also to

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