Lecture 5 Jan20pdf - BIOL 303 Developmental Biology Re-cap...

Info icon This preview shows pages 1–8. Sign up to view the full content.

View Full Document Right Arrow Icon
BIOL 303 - Developmental Biology Processes of morphogenesis: 1. Differential cell affinity 2. Cell shape changes 3. Epithelial-mesenchyme transition Re-cap:
Image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Cell shape changes drive Morphogenesis How does apical constriction and invagination happen on a molecular level? basal apical basal apical à Relocation of small Rho GTPase + β -catenin to apical side à regulates/stabilizes acin-myosin contractile apparatus at apical side à Leads to apical constriction à leads to invagination Developmental Biology, 10e, Fig 3.8
Image of page 2
Gastrulation involves cell shape changes AND epithelial- mesenchymal transition - Snail induces epithelial cells to become mesodermal (mesenchymal) - It does so by repression of the cell adhesion molecule E-cadherin - Twist induces cell shape changes in ventral epithelium - It does so by recruiting Rho-GTPase and β -catenin to the apical side - This regulates/stabilizes the actin- myosin contractile apparatus - Leads to apical constriction - Leads to invagination - Snail-Ecadherin pathway is activated in cancer (it promotes metastasis of tumor cells to distant organs) Snail staining
Image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
BIOL 303 - Developmental Biology © Tamara Western 2013 Induction & Competence 1. Vertebrates 2. C. elegans vulval development (developmental genetics)
Image of page 4
Induc&on and competence Induction : Competence:
Image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Differentiation: Induction & competence Example: the making of a vertebrate eye A) Pair of bulges growing out of the forebrain: à optic vesicle (OV) B) Epidermis overlying the optic vesicle develops the lense placode - OV becomes optic cup becomes retina - Lense placode develops into lense Reciprocal induction:
Image of page 6
Correlation: the lense placode forms where the OV touches the head ectoderm Hypothesis: OV induces placode formation in overlaying ectoderm Test hypothesis: Interpretation (adapted) 2) 3) 4) 1) 5)
Image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 8
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern