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bandtcellshandout - 8:43 PM fig 15-1 B and t Adaptive...

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5/4/08 8:43 PM fig 15-1. B and t Adaptive Immune system o Humoral- DIRECTED AT BACTERIAL INFECTIONS AND EXTRACELLULAR VIRUSES. A system produces Ab and response to microbial invaders and pathogens. Ig=Immunoglobulin=Antibodies Produced by B lymphocytes (B cells) o Cellular- destroys host cells infected by viruses and kill parasites and foreign tissues. T cells responds to virus invaded cells. T cells= T lymphocytes- develop at thymus. T cell receptors Cytotoxic t cells and helper t cells. Helper T cells interact with macrophages. Release cytokines (i.e. interleukins). Participate indirectly in destroy pathogens. Stimulate proliferation of the selective cytotoxic T cells and B cells. clonal selection. Epiptope - a small portion (some stretches of aa) of an antigen recognize by a B cell. B and T fig 15-2 Ig=immunoglobulin=antibody
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has many subtypes, IgG, IgE, IgD, IgM, etc. we focus on IgG. IgG , most common form of antibody, neutralize soluble antigens such as viruses. Fig 24-32. Each of the horseshoe shape is a domain with disulfide linkages. 4 protein subunits in IgG- 2 heavy chains and 2 light chains. Heavy chains are identical (sequences) to each other; light chains are identical (sequences) to each other.
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