MG-section_week_14-answers

MG-section_week_14-answers - 7.03RecitationSectionWeek14...

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7.03 Recitation -- Section Week 14 TA: Mike Gaviño Email: mgavino@mit.edu OH: Tuesday 7-8pm in Stata, first floor Concepts Questions for Lectures #33, 34, 35: 1. How can the genes that govern a specific biological process be identified? What is a genetic screen? What organism(s) might you use for such an experiment? How are mutants generated? What crosses are necessary to find dominant mutant phenotypes? Recessive ones? 2. What is a balancer chromosome? In what organism do such chromosomes exist? What is the purpose of having a visible dominant allele? A recessively lethal allele? Why is it important that balancers carry many chromosomal rearrangements? How does use of a balancer chromosome reduce the number of crosses needed in a genetic screen? 3. Once mutants are identified, how can you tell if a phenotype is due to a loss of gene function (hypomorph) or a gain of gene function (hypermorph)? Are loss of function phenotypes usually recessive or dominant? If a mutant allele is a true loss of function allele, would you expect a homozygous mutant (m/m) to have a stronger, weaker, or the same phenotype as when heterozygous with a complete deletion allele (m/deletion)? What if it is a partial loss of function allele? A gain of function allele? 4. How can you tell in which cells of an organism your mutated gene is
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MG-section_week_14-answers - 7.03RecitationSectionWeek14...

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