chensi_exam4review

chensi_exam4review - 7.05 Exam 4 Review Part II 1. 2. 3. 4....

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7.05 Exam 4 Review Part II 1 1. Metabolism of glycogenic and ketogenic amino acids 2. Metabolism of Serine 3. Metabolism of Phenylalanine and Tyrosine 4. Amino Acid Entry into the TCA Cycle 5. Purine and Pyrimidine Synthesis 1. Metabolism of glycogenic and ketogenic amino acids a. General amino acids breakdown Step 1: Transaminate Step 2: Activate via oxidase particle Step 3: Examine longest carbon chain, if 1 β-Hydrogen then the reaction proceeds analogous to Leucine breakdown 2 β-Hydrogens then the reaction proceeds analogous to Isoleucine breakdown 3 β-Hydrogens then the reaction proceeds analogous to Valine breakdown Generally, reactions follow: O xidize, H ydrate, O xidize and C leave (similar to fatty acid oxidation). b. Leucine b acetoacetate (ketogenic) + acetyl CoA (ketogenic) Enzymes involved: Oxidative particle (NAD, CoA, FAD, lipoate, thymine PP) b attach –SCoA E-biotin-CO 2 b attach CO 2 ATP generated: + NADH = 3 ATP + FADH 2 = 2 ATP
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7.05 Exam 4 Review Part II
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chensi_exam4review - 7.05 Exam 4 Review Part II 1. 2. 3. 4....

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