7.05TA01Answers

7.05TA01Answers - Recitation #1 February 11, 2008 ANSWERS...

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Recitation #1 – February 11, 2008 ANSWERS Lecture 1 – 3: pH and buffers, amino acids, and protein purification Contact Information: Patricia Zheng Email: [email protected] Recitation: Mondays 1pm in 26 210 Format: 20 min review/10 min Q&A /20 min example problems Outline: I. pH and Acid & Base a. Definitions b. Strong Acid c. Weak Acid d. Buffers II. Amino Acids a. Structure and Species b. Condensation c. Amino Acids III. Protein purification Practice Problems Problem 1: 2004 Exam 1
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Problem 2: 1995 Exam 1 Aspirin has a carboxylate group with a pKa of 3.5. Structure = In order to enter the bloodstream, aspirin must pass through the membrane lining the stomach (pH~1) and small intestines (pH~6). In general, electrically neutral molecules pass through a membrane more easily than charged molecules. Would you expect more aspirin to be absorbed in the stomach or small intestines? Why? Aspirin is more readily absorbed through the stomach. At a pH equal to the pKa of aspirin (pH=3.5), half of the ionizable groups (in this case the carboxyl group) are
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This note was uploaded on 02/06/2009 for the course 7 7.05 taught by Professor Unknown during the Spring '09 term at MIT.

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7.05TA01Answers - Recitation #1 February 11, 2008 ANSWERS...

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