Recitation_7-solutions-Simona

Recitation_7-solutions-Simona - Simona Tescu tescu@mit.edu...

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Simona Tescu 04/02/2008 tescu@mit.edu Section 05 Recitation #7 solutions Question 1. C Question 2. A phosphoryl group will introduce two negative charges that can affect the electrostatic interactions within the protein. In addition, a phosphoryl group can form three highly directional hydrogen bonds to adjacent H-bond parteners in the protein. These local effects can be transmitted to more distant parts of the protein in a manner similar to allosteric effects. Question 3. B Question 4. a) increases PKA activity b) decreases PKA activity c) increases PKA activity d) decreases PKA activity e) decreases PKA activity Question 5. There are two significant amplification steps. The binding to one epinephrine to the receptor stimulates the formation of many molecules of G α . In turn, each molecule of G α stimulates the formation of many molecules of cAMP. Question 6. The mutated α -subunit would be defective for signaling because it would be turned “on” all the time, even in the absence of an activated receptor. The inability to turn
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Recitation_7-solutions-Simona - Simona Tescu tescu@mit.edu...

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