BIBC 102 Metabolic Final Notes

BIBC 102 Metabolic Final Notes - BIBC 102 Metabolic Final...

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BIBC 102 Metabolic Final Notes I. Krebs Cycle 1. Krebs cycle is an aerobic process that converts carbs, fats and proteins into C02 and H20 to generate useable energy 2. It is the 3 rd of 4 ATP synthesis cycles A. Synthesis of Citrate and Isocitrate 1. Citrate and isocitrate are prochiral molecules, meaning both sides aren’t equal. 2. With carbon labeling, able to discover that the enzyme that binds to binding site has an asymmetric landing site which means that citrate has to be in a certain stereochemistry in order for enzyme to even bind to it. 3. Because isocitrate is made asymmetrically, it also means that citrate is asymmetrical. B. Anaplerotic Reactions 1. there are four anaplerotic reactions which form the intermedieates of the TCA cycle. 2. Four Reactions: a) Pyruvate + bicarbonate + ATP—(pyruvate carboxylase) Oxaloacetete + ADP + Pi b) Phosphoenolpyruvate + C02 + GDP—(PEP carboxykinase) Oxaloacetate + GTP c) PEP + bicarbonate—(PEP carboxykinase) Oxaloacetate + Pi d) Pyruvate + bicarbonate + NADH—(Malic Enzyme) Oxaloacetate + NADP+ C. Biotin 1. Involved in decarboxylation reactions 2. A small tag added to proteins because it is very good at picking up and removing C02. 3.
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This note was uploaded on 02/07/2009 for the course BIBC BIBC 102 taught by Professor Price during the Winter '08 term at UCSD.

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BIBC 102 Metabolic Final Notes - BIBC 102 Metabolic Final...

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