Lecture 10 - Intracellular Signaling I General Features a Types of Cell-Cell Signaling i Synaptic ii Paracrine signaling involves chemical

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Intracellular Signaling I. General Features a. Types of Cell-Cell Signaling i. Synaptic ii. Paracrine signaling involves chemical secretion that affects a wider range of cells than synaptic, but still remains largely local. iii. Endocrine signaling is the secretion of hormones into the blood stream where they affect cells throughout the entire body b. Signal Transduction i. Intracellular or intercellular amplification is an advantage of signal transduction. Because much more molecular products can be created from the initial quantity of molecular trigger, it grows in effectiveness due to numbers. ii. Greater control is exerted onto the pathway with increased steps available for regulation. c. Receptor Types i. Surface Receptors 1. Cell impermeant a. Channel linked receptors have both receptor and transducing regions located on the same protein molecule. Chemical signals will interact with the binding region and open or close the ion channel pore. b. Enzyme linked receptors have an extracellular site for binding but the intracellular region is composed of an enzyme that performs a catalytic action regulated by the binding site. Most of these receptors are protein kinases that phosphorylates the tyrosine residues on proteins. c. G protein coupled receptors regulate intracellular actions through an intermediate called the GTP binding proteins, otherwise known as G proteins. 2. Cell associated signaling molecules are located on the outer surface of the membrane therefore influence is exerted only if there is cell to cell contact. ii. Intracellular Receptors 1. Cell permeant signaling molecules can pass through the plasma membrane to act of receptors within the cell. To pass through the membrane, these signaling molecules must be insoluble in aqueous solutions, namely blood. Many of the receptors for
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This note was uploaded on 02/07/2009 for the course BIPN BIPN 140 taught by Professor Spitzer during the Fall '07 term at UCSD.

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Lecture 10 - Intracellular Signaling I General Features a Types of Cell-Cell Signaling i Synaptic ii Paracrine signaling involves chemical

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