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Lecture 11 - Synaptic Plasticity I I Short Term Synaptic...

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Synaptic Plasticity I I. Short Term Synaptic Plasticity a. Types i. Synaptic facilitation 1. Increase in synaptic strength that occurs when two or more AP invade the presynaptic terminal within few milliseconds of each other. It is thought to be caused by prolonged elevation of presynaptic Ca levels following synaptic activity. When AP arrive close together in time, Ca builds up within the terminal and allows more NT to be released. ii. Synaptic depression 1. NT release is reduced after sustain synaptic activity. Depression depends on the quantity of NT released, such that lower Ca concentrations reduces the rate of depression and the magnitude of depression is proportional to the amount of NT released. Putting those together this is thought to stem from a depletion of SV. iii. Synaptic augmentation 1. Augmentation enhances the tendency for a SV to fuse with the membrane and release NT. It is thought to have stemmed from prolonged levels of Ca and the Ca subsequently activates the munc 13 protein. iv. Post titanic potentiation (PTP) 1. PTP has a slower time course, but can outlast the augmentation. PTP is thought to
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