Lecture 9 - Neurotransmitter/Receptors I. NT Receptors a....

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Neurotransmitter/Receptors I. NT Receptors a. Ionotropic Receptors b. Metabotropic Receptors II. Classical Neurotransmitters a. Acetylcholine (ACh) i. ACh is synthesized locally from acetyl CoA and choline. Choline acetlytransferase (ChAT) catalyzes the acetyl CoA and choline into acetylcholine (ACh). The presence on ChAT determines whether the neuron is a cholinergic neuron or not. ii. ACh is not recycled but instead cleaved by a rapidly acting enzyme, acetlycholinesterase (AChE) and hydrolyzes ACh into acetate and choline (Choline is transported back into the neuron). iii. Buildup of ACh depolarizes the postsynaptic cell and renders it refractory to subsequent ACh release. iv. Postsynaptic activity of ACh is determined by the nicotinic ACh receptor (nAChR). nAChR are non selective cation channels that generate EPSP. nAChR is composed of 5 subunits, each with 4 TM domains that compose of the channel pore and a long extracellular region for the ACh binding site. b.
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Lecture 9 - Neurotransmitter/Receptors I. NT Receptors a....

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