MCB354FA08_ExamIAKEY - True-False (27 points total, 3...

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1 True-False (27 points total, 3 points each) Select True or False for the following statements. 1. The hydrophobic effect is primarily due to enthalpic considerations, in which ordered water is released into bulk solvent. A. True B. False 2. The loop of amino acids joining the C-terminal end of a β -strand to the N-terminal end of the α -helix in a β - α - β motif in a globular protein often contain D-amino acids, which lend flexibility to this structural feature. A. True B. False 3. Hydrophobic interactions between proteins in aqueous solution are favored because the number of ordered water molecules surrounding the proteins is minimized, giving the system greater thermodynamic stability. A. True B. False 4. The two substrates that participate in the formation of a peptide bond in the solid phase synthesis of a peptide are an unprotected amino terminal of a peptide attached to a solid support and a dicyclohexylcarbodiimide-activated, Fmoc-protected amino acid. A. True B. False 5. Edmund degradation sequencing involves a nucleophilic attack on phenylthioisocyanate (PITC) by the carboxy-terminal end of the target pepetide. A. True B. False
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2 6. Peptide prolyl isomerase catalyzes trans cis isomerism of proline residues, and therefore promotes formation of the β -turns needed for a protein to adopt its folded conformation. A. True B. False 7. F, Y, and W are all classified as aromatic amino acids. A. True B. False 8. Sodium dodecyl sulfate polyacrylamide gel electrophoresis separates proteins according to their charge. A. True B. False 9. The α -carboxylate group of an amino acid has a lower pKa than acetic acid, in part due to the partial positive charges on the α -ammonium tending to repulse, and thus destabilize, the positive charge on the proton of the α -carboxylic acid. A.
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This note was uploaded on 02/09/2009 for the course MCB 354 taught by Professor Spees during the Spring '09 term at University of Illinois, Urbana Champaign.

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MCB354FA08_ExamIAKEY - True-False (27 points total, 3...

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