Bios_41_Lecture_24

Bios_41_Lecture_24 - cAMP Signaling Phospholipase C...

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Chapter 16: Cell Communication Lecture 24 (pages 544-567) March 24, 2008 Jennifer Venditti
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Classes of cell surface receptors
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G-protein-linked receptors transduce signals through activation of G-protein subunits
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All G-protein-linked receptors share a similar structure.
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G-proteins are composed of 3 protein subunits.
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Activation of a G-protein
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The G-protein alpha subunit functions as an intrinsic GTPase
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G-proteins can activate ion channels.
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G-proteins can activate enzymes directly.
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Animation 16.2 G-protein signaling
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cAMP has many effects within the cell.
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A G-protein activates adenylyl cyclase
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Animation 16.3
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Unformatted text preview: cAMP Signaling Phospholipase C activates two signaling pathways in the cell. Ca 2+ signaling is important for many biological processes in the cell. Animation 16.4 Inositol Phosphate Signaling Enzyme-linked receptors transduce signals upon activation of the enzyme by a signal. Enzyme linked receptor: Receptor Tyrosine Kinase Receptor Tyrosine Kinases (RTK) activate Ras proteins. Ras activates a MAP-kinase phosphorylation cascade. MAP-kinase Signaling Animation http://www.bio.davidson.edu/courses/Immunology/Flash/MAPK.html Signaling pathways can be connected to one another....
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This note was uploaded on 04/19/2008 for the course BIOS 41 taught by Professor Sands during the Spring '08 term at Lehigh University .

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Bios_41_Lecture_24 - cAMP Signaling Phospholipase C...

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