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BIOS41_Lecture25_03262008

BIOS41_Lecture25_03262008 - cyclin is bound 18_06_M_Cdk The...

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BIOS 41 Biology Core I: Cellular and Molecular Spring 2008 Lecture 25, March 26 Cell-Cycle Control (Chapter 18, pages 611-625)
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18_01_cell_cycle.jpg Overview of the Cell Cycle
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18_02_four_phases.jpg The Eucaryotic Cell Cycle is Divided into Four Phases.
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18_04_Feedback.jpg Feedback from the intracellular events of the cell cycle, as well as signals from the cell’s environment, determine whether the control system will pass through certain checkpoints.
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18_05_ Cdks.jpg Progression through the cell cycle depends on cyclin-dependent protein kinases (Cdks) “Cyclical changes in cyclin concentrations help drive the cyclic assembly and activation of the cyclin-Cdk complexes; activation of these complexes in turn triggers various cell- cycle events, such as entry into S phase or M phase.” page 616. Cdk active only when
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Unformatted text preview: cyclin is bound. 18_06_M_Cdk.jpg The rise and fall of M-Cdk activity during the cell cycle. “The sudden fall in M-cyclin concentration toward the end of mitosis is the result of its rapid destruction by the ubiquitin-dependent proteolytic system.” page 617. 18_07_cyclin_degradat.jpg The activity of Cdks is regulated by cyclin degradation. 18_13_Cdks_cyclins.jpg Different cyclin-Cdk complexes trigger different stages in the cell cycle. 18_15_cell_cycle_G1.jpg DNA damage arrests the cell cycle in G1. “One of the best understood checkpoint mechanisms halts the cell cycle in G1 if DNA is damaged, helping to ensure that a cell does not replicate damaged DNA.” page 623. 18_17_arrest_checkpt.jpg The cell-cycle control system can arrest the cycle at various checkpoints....
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BIOS41_Lecture25_03262008 - cyclin is bound 18_06_M_Cdk The...

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