BIOS41_Lecture22_03192008

BIOS41_Lecture22_03192008 - Presenter: Christina P. Sie...

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Presenter: Christina P. Sie Lecture 22, March 19 Cellular Cytoskeleton, conclusion (Chapter 17, p. 592-606)
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Actin is essential for cell shape and cell motility gut cells cellular “muscles” at leading edge of crawling cells Microvilli Contractile bundles Lamellipodia and filopodia Contractile ring pinches cytoplasm in two during cell division
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Actin filaments at the molecular level 7nm Actin filaments are thin, flexible protein threads Two-stranded α -helix Polarity!
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Actin filaments are dynamic F-actin (filamentous actin) G-actin (globular actin) Plus end (growing) Minus end (shrinking) Nucleotide hydrolysis in F-actin promotes depolymerization
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17_32_Actin_binding.jpg Actin-binding proteins determine structure and dynamics Accessory proteins tailor actin structure and dynamics for specific cellular functions
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Figure 17-36 Essential Cell Biology, 2/e. (© 2004 Garland Science) Figure 17-34 Essential Cell Biology, 2/e. (© 2004 Garland Science) Actin in cell migration Cells move by crawling:
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This note was uploaded on 04/19/2008 for the course BIOS 41 taught by Professor Sands during the Spring '08 term at Lehigh University .

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BIOS41_Lecture22_03192008 - Presenter: Christina P. Sie...

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