DNA Replication - DNA Replication Dr. Michael Henshaw BIO...

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1 DNA Replication Dr. Michael Henshaw BIO 120 - General Biology I Winter 2008 Lecture# - 14 Associated Reading – Ch. 16
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2 Study Guide When was the structure of DNA elucidated? Who first constructed a realistic model for DNA structure? Review the structure of DNA molecules How does the structure of DNA relate to its replication? How is DNA replicated? What is a replication bubble? Replication fork? How is replication terminated? How are new nucleotides added? What enzymes are involved? What is continuous and discontinuous synthesis and why is it necessary? Know the steps of synthesis
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3 In 1953, James Watson and Francis Crick published an elegant double-helical model for the structure of deoxyribonucleic acid, or DNA DNA, the substance of inheritance, is the most celebrated molecule of our time
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4 Building a Structural Model of DNA: Scientific Inquiry Earlier work convinced most biologists that DNA was the hereditary material, the challenge was to determine how its structure accounts for its role They knew DNA was composed of nucleic acids, but not how they were fit together
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5 LE 16-7 5 end 3 end 5 end 3 end Space-filling model Partial chemical structure Hydrogen bond Key features of DNA structure 0.34 nm 3.4 nm 1 nm
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6 The structure of DNA is tied to its replication and repair Watson and Crick noted that the specific base pairing suggested a possible copying mechanism for genetic material
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7 This semiconservative model of replication predicts that each daughter molecule will have one old strand (derived or “conserved” from the parent molecule) and one newly made strand
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8 Replication begins at special sites called origins of replication , where the two DNA strands are separated,
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DNA Replication - DNA Replication Dr. Michael Henshaw BIO...

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