L104_H7_Cancer_S2008-3

L104_H7_Cancer_S2008-3 - L104 Cancer Campbell et al.,...

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L104 Cancer Campbell et al., Essential Biology with Physiology Cell Cycle Control – Chapter 8 - Cellular Basis of Inheritance and Reproduction. Page 128-129 The Genetic Basis of Cancer - Chapter 11- Page 211-215 Genes that cause cancer: Oncogenes and Tumor Suppor Genes Oncogene A gene that causes cancer. Frequently an altered version of a normal gene Proto-Oncogene o A gene with the potential to become an oncogene o May be acquired from viruses o Conversion of one of it’s own genes o Code for growth factors – stimulate cell o division o Formed by mutation within a gene, amplification, translocation to a new locus under new controls.
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Tumor suppressor genes Inhibition of these – involvement in cancer. Many tumor suppressor genes code for genes involved in signal transduction pathways regulating gene expression Altered signal transduction pathway E.g. ras – normally involved in cell signal transduction leading to growth stimulation. Mutation in ras – pathway over-
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This note was uploaded on 04/18/2008 for the course BIOL-L 104 taught by Professor Odle during the Spring '08 term at Indiana.

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L104_H7_Cancer_S2008-3 - L104 Cancer Campbell et al.,...

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