Chapter 16 - Chapter 16 Glycolysis (intermediates,...

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Chapter 16 Glycolysis (intermediates, irreversible steps, G® ‘ ) The rate of glycolysis is determined by the concentration of glucose. Is the sequence of reactions that converts glucose into pyruvate with the concomitant production of a relatively small amount of adenosine triphosphate (ATP). Glucose phosphorylation catalyzed by hexokinase; fructose- 6-phosphate phosphorylation catalyzed by phosphofructokinase; and phosphoryl transfer from PEP to ADP catalyzed by pyruvate kinase.
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Fates of Pyruvate
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NADH made by G3PDH rxn must be reoxidized to NAD+ for glycolytic pathway to continue. Alcohol Dehydrogenase oxidizes NADH and generates ethanol (alcohol fermentation). Lactate dehydrogenase oxidizes NADH while generating lactic acid (lactic acid fermentation) Rossman Fold- similar in Glyceraldehyde 3 Phosphate dehydrogenase, alcohol dehydrogenase and lactate dehydrogenase. 4 helices 6 parallel strands. Has to be there α β when there’s NAD or NADH, it’s a cofactor binding moiety of the protein, lobe of protein good at binding NAD, usually in redox enzyme How Galactose and Fructose enter Glycolysis Galactose 1. Galactose phosphorylated to galactose 1 phosphate by galactokinase. 2. Galactose 1 phosphate gets uridyl group from UDP glucose, catalyzed by galactose 1 phosphate. Uridyl transferase products are UDP-galactose and glucose 1 phosphate. 3.
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This note was uploaded on 04/18/2008 for the course BIOCHEM 694:301 taught by Professor Deis during the Spring '08 term at Rutgers.

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Chapter 16 - Chapter 16 Glycolysis (intermediates,...

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