Chap 6 - Chap 6 Hemoglobin is a tetramer (A tetramer is a...

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Chap 6 Hemoglobin is a tetramer (A tetramer is a protein with four subunits) 2 2 α β Myoglobin is a monomer Homologs – proteins that come from same ancestor divided into orthologs and paralogs Orthologs – derive from a speciation event Paralogs - from gene duplication event Ex) human hemoglobin is an ortholog of chimp hemoglobin but a paralog of chimp/human myoglobin The duplication event (Hb/Mb) took place hundreds of millions of years ago, but speciation event took place 6 million years ago. Sequence Alignment- is a way of arranging the primary sequences of DNA, RNA, or protein to identify regions of similarity that may be a consequence of functional, structural, or evolutionary relationships between the sequences Shuffling a Sequence – AA shuffled then aligned, random rearrangement, shows these a greater homology between myoglobin + hemoglobin before shuffling sequence How can you tell where to align the 2 sequences? (Without gaps) Compare all juxtapositions of one protein sequence with another, in each case recording the number of
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This note was uploaded on 04/18/2008 for the course BIOCHEM 694:301 taught by Professor Deis during the Spring '08 term at Rutgers.

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Chap 6 - Chap 6 Hemoglobin is a tetramer (A tetramer is a...

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