minerals - VITAMINS & MINERALS Maggie Murphy October...

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Maggie Murphy October 30, 2007 Momurp3@uky.edu
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Folic Acid Food Sources Orange Juice Dark leafy vegetables “Enriched” grain products Supplements--daily multivitamins
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Components Made up of three distinct parts , all of which must be present for vitamin activity Pteridine PABA Glutamic acid
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Functions Primary function of folate coenzymes is to accept or donate one-carbon units Amino acid metabolism Formation of S-adenosylmethionine (SAM)
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Functions First folate is converted to DHF (dihydrofolate) & then to Tetrahydrofolate (THF) THF derivatives serve as the one- carbon donors in a variety of synthetic reactions These reactions permit the conversion of Glycine-->serine Homocysteine-->methionine
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Homocysteine If increased levels, increased risk of coronary heart disease work together in this reaction--need B12 to remove a methyl group from N5 methyl THF (one of the THF derivatives)
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Deficiency Abnormal DNA synthesis Neural Tube Defects Folic acid reduces 75% of these defects Spina bifida Paralysis Learning disabilities Respiratory problems anencephaly
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Vitamin B12 Food sources Dairy products Eggs Seafood--shellfish B12 fortified products Cereals, meat substitutes, soy milk
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Components Also known as cobalamin (contains cobalt) Cyanocobalamin &hydroxycobalamin- most active forms Cyanocobalamin produced commercially from bacterial fermentation (form found in supplements) Unlike other water soluble vitamins, B12 can be stored in the body
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minerals - VITAMINS & MINERALS Maggie Murphy October...

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