Lecture47-BIO150-Rowe-07-08 - Evolutionary Medicine Prof...

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Copyright © 2008 Locke Rowe Evolutionary Medicine Prof. Locke Rowe Lecture 47 The Evolution of Resistance, and Medical Phylogenies Required reading: none Key words/concepts/terms: resistance, generation time 1. Evolution of drug resistance: (a) malaria and quinine, (b) bacterial infections and antibiot- ics, (c) HIV and treatment with AZT 2. Phylogenetics of evolutionary medicine: (a) origin and timing of disease evolution, (b) mechanisms of disease evolution 1. There has been a general decline in the effectiveness of several medical solutions for fighting disease in recent history. The reason for this is two-fold. First, new treatments aren’t being developed very quickly. Second, drug treatments impose strong selection on viruses and bacteria, favouring resistant strains. Therefore, the evolution of drug resistance can occur extremely quickly because most microbes have short generation times. We will focus on this latter problem. (a)
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This note was uploaded on 04/18/2008 for the course BIO 150 taught by Professor Rowe during the Spring '08 term at University of Toronto.

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Lecture47-BIO150-Rowe-07-08 - Evolutionary Medicine Prof...

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