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SIU School of Medicine BIOCHEMISTRYpH and Structural BiologyFaculty: J.W. ShriverProblem Unit 1 - Page 1MEDICAL BIOCHEMISTRYProblem Unit One1999/2000pH and Structural BiologyModule 1: Acid/Base Properties of BiomoleculesModule 2: Amino Acids, Peptides, and ProteinsModule 3: Structural Biology and Disease
SIU School of Medicine BIOCHEMISTRYpH and Structural BiologyFaculty: J.W. ShriverProblem Unit 1 - Page 2Faculty: Dr. John W. ShriverDepartment of Biochemistry and Molecular BiologyOffice: 289 Neckers Bldg.email: [email protected]Telephone: 453-6479LEARNING RESOURCES:ESTIMATED WORK TIME: 40 hours.A. This study guide is provided in two forms: printed and electronic.I strongly encourage you to obtain the electronic form as a pdf fileand install it on your computer so that it can be read using AdobeAcrobat Reader.See Appendix II for an introduction on how toview a pdf file. The pdf file can be downloaded from the biochemis-try server () and AcrobatReader can be downloaded without charge from Adobe’s web page(). They should also be installed onthe student computers. There are a number of advantages to usingthe electronic version including color, a hypertext index, and hyper-text links within the text. Hypertext links in the text body are in blueunderlined characters (such as this). Clicking on these will lead to ajump to the linked material for further details. The destination mate-rial is highighted with red underlined characters (such as this) tomake it easy for you to find on the page. The red underlined text isnot a hyperlink - only a destination. This and other study guides are provided to help you focus on thetopics that are important in the biochemistry curriculum. These aredesigned to guide your studying and provide information that maynot be readily available in other resources. They are not designed toreplace textbooks, and are not intended to be complete. They areguides for starting your reading. The pdf electronic versions shouldbe especially useful for quick reviews at a later date. The hypertextNomenclature and Vocabulary sections should permit rapid scanningof the key points.B.Textbooks: 1.Devlin, Textbook of Biochemistry with Clinical Correla-tions, Thomas. Core text for Medical Biochemistry.2.Champ & Harvey, Lippincotts Illustrated Reviews of Bio-chemistry, current ed., Lippincotts. Efficient presentation ofbasic principles. 3.Murray et al., Harper's Biochemistry, (23rd ed.) ('93), Pren-tice-Hall, Inc. An excellent review text for examinations.
SIU School of Medicine BIOCHEMISTRYpH and Structural BiologyFaculty: J.W. ShriverProblem Unit 1 - Page 3Most textbooks of biochemistry contain sections on pH and dissocia-tion and protein structure; some are more extensive than others. Anybiochemistry textbook that covers the subject in sufficient detail soyou can answer the questions in the Problem Sets and Practice Examshould be sufficient. Additional material can be found on the web at