ANSWERS TO MYELOPROLIFERATIVE AND BLEEDING DISORDERS LAB 2

ANSWERS TO MYELOPROLIFERATIVE AND BLEEDING DISORDERS LAB 2...

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SAMUEL MERRIT COLLEGE PROBLEM BASED LEARNING ANSWERS MYELOPROLIFERATIVE DISORDERS CASE 1 HIGH HEMATOCRIT A 55-year-old male was admitted to the hospital for an elective herniorrhaphy. The preoperative work up revealed a hematocrit of 56, and surgery was delayed. What is the first step you will consider in a patient with elevated Hct? You must distinguish between transient, relative and persistant rise in Hct Six months before this admission he was told that he had “too much blood”, and a review of his records revealed elevated Hct levels recorded on two separate occasions during the previous year. Describe the pathophysiologic classification (differential causes) of patient who has persistently elevated Hct levels? Primary: PRV Secondary: To hypoxia To inappropriate secretion of Erythropoietin Relative: Dehydation How do differentiate absolute erythrocytosis from relative erythrocytosis? Red cell mass Differentiate between physiologically appropriate and inapropriate polycythemia? Arterial oxygen saturation Describe the pathophysiology of P. vera? CFU-E abnormal clone in PRV form colonies even in absence of erythropoietin stimulation. Malignant transformation of single clone of pluripotent stem cells with prmary commitment to erythroid series. 37
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On further questioning the patient admitted to a 30 pack-year cigarette history. He had a chronic morning cough productive of small amount of brown sputum, but he had no shortness of breath. He had been a heavy drinker but had not had any alcohol intake for more than 5 years. Recently he spent a 2 weeks vacation
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This note was uploaded on 04/19/2008 for the course PATHOLOGY pathology2 taught by Professor Dr.mahmood during the Spring '08 term at Samuel Merritt.

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ANSWERS TO MYELOPROLIFERATIVE AND BLEEDING DISORDERS LAB 2...

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