Learning Objectives Metabolism

Learning Objectives Metabolism - Ms Olsons Learning...

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Ms. Olson’s Learning Objectives Metabolism Learning Objectives Lecture 23 - The absorptive state and insulin (CT 12.2) 1. Describe the journey that glucose, amino acids take from their site of absorption in the GI tract to the peripheral cells where they are used and stored. Remember for our discussions of the GI tract that amino acids and sugars are absorbed into the venous blood and carried by the hepatic portal vein to the liver. Carbohydrates are broken down into glucose, which then is stored in the plasma of the blood. The body uses glucose for metabolism in the brain first and then in most tissues. If there is excess glucose, the liver converts glucose into glycogen and then turns further glucose into fat. Proteins are broken down into amino acids. First, protein synthesis occurs to replace damaged body proteins and then excess amino acids are converted into glucose (gluconeogenesis) 2. Explain how glygcogenesis (synthesis of glycogen) and lipogenesis (synthesis of fat) in the liver prevent large spikes of plasma glucose after a meal. When plasma glucose gets above normal range, glucose is converted into glycogen (glycogenesis) and then when glycogen stores are filled excess glucose is converted to fat (lipogenesis) 3. Discuss the storage of absorbed triglyceride from a meal and triglycerides synthesized by the liver. Remember that a TGL is three fatty acids covalently bound to a glycerol backbone. This the most abundant energy storage molecule in the body Fat is broken down into cholesterol, free fatty acids, and triglycerides. Chylomicron is a fat transporter.
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