Genetics Study Guide - Genetics Study Guide Chapter 14 RNA...

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Genetics Study Guide : Chapter 14 – RNA Molecules and RNA Processing 1902, Archibald Garrod – suggested that genes encode proteins  a gene contains the nucleotides that specify the amino acids of a protein 1958, Francis Crick – proposed that genes are proteins are collinear Colinear – that there is a direct correspondence between the nucleotide sequence of DNA and the amino acid sequence of a protein  that the number of nucleotides in a gene should be proportional to the number of amino acids in the protein encoded by that gene  this is true for genes of bacterial cells and many viruses, even though there genes are slightly longer if colinearity were strictly applied – the mRNAs encoded by the genes contain sequences at their ends that do not specify amino acids  not are genes are continuous – eukaryotic virus was discovered with four coding sequences interrupted by nucleotides that didn’t specify for amino acids Eukaryotic genes consist of stretches of coding and noncoding nucleotides. Eukaryotic Genes Exons – coding regions Introns – noncoding regions (intervening sequences) Introns vs. Exons  average human gene contains 8-9 introns  introns and exons are initially transcribed into RNA, but after transcription the introns are removed by splicing and the exons are joined to yield the mature RNA *Introns are common in eukaryotic genes but rare in bacterial genes.
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