03 FYI Amino acids - AA POGIL Activity Learning objectives...

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AA POGIL Activity Learning objectives: Predict the charge on a functional group or a molecule given their pKa and pH. Estimate the pI of an amino acid, peptide, or protein Diagram the stereochemistry of the peptide bond Explain the structure of the peptide bond, and its consequences for protein folding
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Peptide Bonds Linear Polymers N- Terminus C- Terminus
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VVP, Page 129 Resonance of the Peptide Bond C N = 1.49Å C=N = 1.27Å Peptide Bond = 1.32Å (Partial Double Bond Character) No Free Rotation Planar
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VVP Figure 6-3 Extended Conformation of a Polypeptide
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How many charged functional groups are present on the peptide below at physiological pH ? A. 1 B. 2 C. 3 D. 4 E. 5 Arg-Asp-Cys-Tyr-Gln-Val-Glu
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How many charged R groups are present on the peptide below at physiological pH? A. 1 B. 2 C. 3 D. 4 E. 5 Arg-Asp-Cys-Tyr-Gln-Lys-Glu
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Function of proteins largely due to properties of constituent amino acids Catalysts and Metabolic Regulation Enzymes Protection Serum antifreeze, Blood coagulation, Antibodies Transport Across membranes, hemoglobin Signal Transduction Cell Surface Receptors Structural Support Collagen Coordinated Motion Muscle Contraction Genetic Regulation DNA Binding Proteins Nutrient Storage
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