Lecture17 - Theta rhythm and Sharp Waves Sharp wave...

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Theta rhythm and Sharp Waves Theta rhythm is a 6-8 Hz oscillation that occurs during voluntary movement, such as when the rat is navigating through its environment Sharp wave ripples (SWRs) are synchronous bursts of activity that occur mainly during quiet wakefulness (when theta is absent) EEG signal recorded at a specific location is called the local field potential, or LFP.
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Compressed replay during slow-wave sleep (SWS) During SWS, place cells generate spatially ordered burst sequences that are compressed by 10-20x in time From Lee & Wilson, Neuron 36:1183, 2002 Bursts are time-locked to SWR events in the EEG
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Compressed replay and memory consolidation In humans, brain regions activated during VR navigation are reactivated during SWS, and degree of reactivation is correlated with subsequent spatial memory recall Peigneux et al., Neuron 44:535, 2004 Ego-Stengel & Wilson, Hippocampus 20:1, 2010 In rats, when SWR events are disrupted by electrical stimulation after each training trials, maze learning is slowed down
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