OR drugs - Generic/Trade name Classification Mechanism of...

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Generic/Trade name Ketamine HCl/Ketalar Classification Dissociative anesthetic Mechanism of Action NMDA receptor antagonism Dosage and Route 2.5 mg/kg IV once for loading dose, 0.5 mg/min IV infusion for maintenance Is this a Safe Dose? Yes, max loading dose is 4.5 mg/kg and max maintenance dose is 0.5 mg/min IV infusion Drug/food Interactions Doxapram, elvitegravir, epinephrine, epinephrine racemic, fentanyl, fentanyl intranasal, fentanyl iontophoretic transdermal system, fentanyl, idelalisib, isocarboxazid, ivacaftor, memantine, norepinephrine, phenelzine, phenylephrine po, rasagiline, selegiline, sodium oxybate, tranylcypromine Side Effects / Adverse Reactions HTN, increased cardiac output, increased ICP, tachycardia, Tonic-clonic movements, visual hallucinations Lab / VS needed prior to administration of each dose O2, BP, HR Nursing Considerations Monitor vitals closely during initial dose and follow-up observations of medication effectiveness. Check vitals, effectiveness, and tissue oxygenation q4hr after initial dose
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