Exam 3-2-keys (1) - NAME Exam 3-2 Bio E 201 Total=...

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NAME: Exam 3-2 Bio E 201 Total= /100 Biomedical Imaging / 11 1. Angiography is a form of X-ray imaging applied to visualizing blood vessels . (2 points) 2. Both computed tomography and magnetic resonance imaging offer 3D visualization of soft tissues. If you needed to monitor the growth of a tumor on a monthly basis, which technique would you choose and why? (3 points) MRI because you can see blood vasculature into the brain. 3. List 2 pros and 2 cons of PET imaging? (4 points) PROS Shows funcJon Some isotopes easy to make in hospital cheaply Inexpensive hardware (except PET) CONS Poor spaJal resoluJon Uses radiaJon Requires a cyclotron in the hospital for PET 4. What is the main advantage of MRI? (2 points) PROS Good soN Jssue contrast Excellent spaJal resoluJon VersaJle No radiaJon Non-- invasive Drug Delivery / 20 1. Drugs administered through subcutaneous administration reach a peak concentration in the blood slower than after intramuscular administration because_ the drug needs to diffuse to have access to blood vessels : (2 points) 1
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2. Convection of the drug from the blood to the tissue is controlled by a gradient of ___ pressure ______________. (2 points) 3. What are the 3 major advantages of drug delivery systems? (3 points) Increased patient compliance/ increased safety/protect drug from degradation/improve therapy 4. What is the difference between dispersed and dissolved drug into a matrix? (4 points) Dissolved: no phase separation Dispersed: phase separation (crystals) 5. Describe the release mechanisms for both release profiles below? (4 points) 2
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Diffusion + erosion (top) Diffusion (bottom) 6. Conjugated drugs on the surface of nanoparticles are released _ slower ________ (1 point) than adsorbed drugs on the surface of the nanoparticles because ___ chemically attached to the surface ________________________________________? (2 points) 7. Minimum Efficiency Dose (MED) is:
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