Biomaterials-Lecture 2(2)(1) (1)

Biomaterials-Lecture 2(2)(1) (1) - BioE 201 Factors...

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* BioE 201 Factors Governing Degradation Chemical composition Molecular weight Crystallinity Hydrophilicity/Hydrophobicity Geometry
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* BioE 201 Degradation of PLGA
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* BioE 201 Natural Polymers as Biomaterials Collagen Hyaluronic Acid-lubrication, wound healing Chitosan-wound healing Cellulose-plant polysaccharide-filtration membranes In the native form, all naturally derived polymers are inherently biodegradable, however chemical modifications can be used to dramatically slow degradation.
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* BioE 201 Polymer Synthesis Addition Polymerization - chain reaction, involves initiation, propagation, and termination, initiators can be free radical, cation, anions, catalysts, that open a bond, usually a double bond to create a new initiation site for further growth, until terminated Condensation Polymerization - stepwise growth, formation of a covalent bond with the release of a small molecule like water, CO 2 , HCL, methanol, stops when one reagent is used up
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* BioE 201 Free Radical Polymerization free radical-an atom or group of atoms with an unpaired electron
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* BioE 201 Condensation Polymerization
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* BioE 201 SEC / GPC Size exclusion chromatography / gel permeation chromatography
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