Matt - Handout 2 key - IA Matthew Chan Section Thurs...

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IA: Matthew Chan Email: [email protected] Section: Thurs 7-8pm @Center 201 OH: Thurs 5:30-6:30pm @ PC Theater Handout 2 Topics Covered Active Transport Primary Active Transport Secondary Active Transport GLUT Transporters Glucose Transport: Primary/Secondary Activate Transport + Facilitated Diffusion Ionic Current Equilibrium Potential and the Nernst Equation GHK equation Resting membrane potential Active Transport 1. Review: Passive diffusion The diffusion of a substance down its concentration gradient without the use of a protein channel/transporter 2. Review: Facilitated diffusion The diffusion of a substance down its concentration gradient with the aid of a protein channel/transporter 3. Active transport- Transport of a substance across the membrane against its chemical and/or electrical gradient. This requires energy input. Primary Active Transport 1. Def: Movement of a substance across the membrane against its concentration gradient with ATP as the source of energy. 2. Transporters that use ATP for active transport are known as ATPases . The one discussed in lecture is known as the Na+/K+ ATPase or pump s a. Write out the full equation of this transporter. 3Na + (in) + 2K + (out) +ATP 3Na + (out) + 2K + (in) + Pi + ADP b. Briefly discuss the mechanism of action of this transporter i. 3 Na + from ICF bind with high affinity ii. ATP binding and hydrolysis iii. Phosphorylation of ATPase conformational change iv. Release of 3Na + in to the ECF v. 2K + bind from ECF with high affinity vi. ATPase dephosphorylated conformational change vii. 2K + released to ICF c.
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