Midterm 1 Study Guide(1) - Tania Nag Email [email protected]

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Tania Nag Email: [email protected] Section: Monday 2-2:50PM, WLH 2112 OH: Monday 3-3:50 PM, PC Theater Lobby BIPN 100 Midterm 1 Study Guide **Not everything discussed in class and readings is on this study guide. ** Diffusion Osmosis Tonicity Membrane proteins: transpoters (primary/seconday) Ohm’s Law Fick’s Law Resting Potential Nerst equation GHK equation Graded potential Properties Action Potential Properties Conduction Effects of myelin and axon diameter Synaptic transmission Electrical+ chemical synapses Presynaptic events Postsynaptic events Types of receptors -ionotropic -metabatropic excitatory and inhibitory synapses convergence and divergence long term potentiation (LTP) hypo-hyper kalemia hypo-hyper natremia synaptic transmission types of neurotransmitters (Ach) Nicotinic (ion channels) receptors/ cholinergic receptors/ Curare/ myasthenia gravis/ botox Muscarinic receptors (GPCRs) Atropine/ belladonna
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Tania Nag Email: [email protected] Section: Monday 2-2:50PM, WLH 2112 OH: Monday 3-3:50 PM, PC Theater Lobby What is E ion ? E ion is the equilibrium potential of an ion. For example, lets look at K+… K+ is concentrated high inside the cell and low outside the cell, so K+ wants to move down its concentration gradient and leave the cell. At the same time, the inside of the cell has a net negative charge (due to Proteins (Pr-)). Therefore all the Pr- and other negative ions pull K+ back into the cell. The point at which these two forces are balanced = the equilibrium potential of K+. To find the Eion use the Nerst Equation. * Review the equation and also taking logs with base tens* * remember that chlorine is a – charge when plugging in for z* Membrane potential (Vm) is largely due to the K+, but is also influenced by other ions. Therefore to find the value of Vm, use the Goldman-Hodgkin-Katz (GHK) *** When working on problems with GHK remember the permeability coefficients and remember to be careful when plugging in the values for chlorine*** Action Potential Nerst Equation: Eion=(61/z)log[(ion)out/log(ion)in] GHK Equation: Vm is influenced by (2) main factors Ion concentration gradient Permeability of that ion Basic Terms Depolarization= Vm becomes less negative Repolarization= Vm comes back to normal Vm Hyperpolarization= Vm becomes more negative * if Vm changes say from -70mV to +30mV, it doesn’t mean that the concentration gradient has reserved. Only a FEW ions, like 1 K+ ion/ 1000K+ moving inside or outside of the cell changes Vm by 100mV * How can you change permeability? By opening/closing existing channels (most likely)
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Tania Nag Email: [email protected] Section: Monday 2-2:50PM, WLH 2112 OH: Monday 3-3:50 PM, PC Theater Lobby By adding new channels in membrane (this is less likely because it is a slow process)
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