1500 Lecture 9W How genes work

1500 Lecture 9W How genes work - HOW GENES WORK I History...

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HOW GENES WORK I. History of DNA investigation II. How does DNA work? III. Cloning DNA IV. Genetic Engineering & Recombinant DNA Prof. L. Molot ENVS 1500 9W March 7, 2016
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History of the Discovery of DNA 1868 Johann Miescher investigated the chemical composition of the nucleus and found a phosphorus rich organic acid Deoxyribonucleic Acid
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The Mystery Thinking was until mid 20 th century: Heritable traits are diverse so molecules encoding traits must be diverse Heritable material was originally believed to be an unknown class of proteins because they are made of 20 amino acids and are structurally very diverse Researchers knew of DNA, but thought it was too simple in structure to actually be the genetic material.
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1928 Frederick Griffith Griffith, an army medical officer, isolated two strains of bacteria Streptococcus pneumoniae. Studies showed that Rough strain was harmless Smooth strain was lethal
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Live harmless strain Live lethal strain Dead harmless strain Live harmless strain + dead harmless strain In the late 1920's Frederick Griffith mixed dead (heat- killed) lethal bacteria with live harmless bacteria and injected the mixture into mice. The mice died! Why?
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