13practiceset1 - BIO 3102 MOLECULAR EVOLUTION PRACTICE...

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BIO 3102 MOLECULAR EVOLUTION - PRACTICE SET #1 Winter 2013 1. For the homologous sequences #1 and #2 shown below, give arguments either FOR or AGAINST them being under strong functional constraint. (Tip: On a test, you would be given a genetic code table.) #1 5' ... C G T T A C C G T T C G A G A A C T T G T G C A ... 3' #2 5' ... C G A T A C C A T T T G A T A A T C T G T G T A ... 3' 2. Explain why you AGREE or DISAGREE with each of the following statements. i) Four-fold degenerate sites evolve more rapidly than other nucleotide sites. ii) Indels are expected to occur less frequently than point mutations. iii) In a DNA sequence, the 4 bp motif GACT is expected to occur twice as frequently as the 8 bp stretch AAGAGGAG. iv) The “stick insect” wing study (discussed in class) provides a good example of Kimura’s neutral theory. 3. For protein Y which is 200 amino acids long, approximately how many non-synonymous sites are expected in its mRNA? (This question was given in class when we discussed Table 1.5 at the end of Topic 1).
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