13practiceset3 - BIO 3102 MOLECULAR EVOLUTION PRACTICE...

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BIO 3102 MOLECULAR EVOLUTION PRACTICE SET #3 Winter 2013 QUESTION 1 In rats and mice (divergence 25 Mya), there are 2 genes coding for protein P (designated gene P1 and P2), whereas mammals other than rodents have only one copy of the gene. Genes P1 and P2 were sequenced from both rat and mouse, and all copies were found to have an intron of 250 nt. The table below shows the number of nt differences within the intron sequence in pairwise comparisons. Mouse gene P1 Mouse gene P2 Rat gene P1 Mouse gene P2 34 Rat gene P1 30 33 Rat gene P2 32 26 36 Approximately how long ago was this gene duplicated? Show your calculations and give your rationale. QUESTION 2 The schematic below shows proteins which contain an SCP domain (SCP = “sterol carrier protein”) from various organisms. The SCP domain is shown by dark circles, and other domains are: star = thiolase; triangle = hydratase; box = dehydrogenase I; hexagon = dehydrogenase II; cross = stomatin. Draw a clearly-labelled up-to- date “tree -of- life” (with approximate timescale)
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