L18 skeletal II post - Skeletal muscle Differentiate...

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Skeletal muscle Differentiate between myocyte, myofibrils, thin and thick filaments; microfilaments, and sarcomeres; Understand the arrangement & the functions of each protein in a sarcomere; Predict relative contractile force based on sarcomere length. Outline the sliding filament theory, while being able to mention all filaments involved. Give detailed description of cross bridge formation and the power stroke Predict how changes in ATP availability or experimental modification will affect muscle contraction, based on the sliding filament model. Outline the sequence of events between AP reaching the axon terminal of the motor nerve and the increase of [Ca ++ ]cytosol Predict how changes in [Ca 2+ ] levels will affect contractility Explain how cytosolic [Ca ++ ] is regulated Understand the relationship between AP and contraction of the skeletal muscle cell Thursday, March 19, 2015
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Ca 2+ binding causes conformational shift in troponin/tropomyosin, unblocking the myosin-binding site Thursday, March 19, 2015
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What are the stages of the cross-bridge cycle, and how are they regulated?
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  • Fall '13
  • Thursday, sarcomere  length

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