L19 skeletal III post - Skeletal muscle Predict how changes...

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Skeletal muscle Predict how changes in ATP availability or experimental modification will affect muscle contraction, based on the sliding filament model. Predict how changes in [Ca 2+ ] levels will affect contractility List the various factors that contribute to the force generated by skeletal muscles. Differentiate between the contractile and the elastic elements in a muscle Compare and contrast between isometric, shortening and lengthening contraction Tuesday, March 24, 2015
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Single muscle fiber contraction: Twitch Tuesday, March 24, 2015
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Requirement for ATP and Ca 2+ “What happens if ATP is gone, but we don’t have any Ca 2+ either?” Tuesday, March 24, 2015
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“What happens if ATP is gone, but we don’t have any Ca 2+ either?” Predict what will happen to the tension produced in the muscle below at each of the indicated points. Randall et al., 1997 Tuesday, March 24, 2015
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“What happens if ATP is gone, but we don’t have any Ca 2+ either?” Predict what will happen to the tension produced in the muscle below at each of the indicated points. Randall et al., 1997 Tuesday, March 24, 2015
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Skeletal muscle: Force generation How is force generated within a particular muscle fibre? mechanism of contraction of a sarcomere sarcomere length frequency of stimulation How is force generated in an entire muscle? number of fibres stimulated size of fibres stimulated Tuesday, March 24, 2015
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Force generated depends on: Frequency of stimulation After each stimulus, the muscle recovers Tuesday, March 24, 2015
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Treppe : each contraction stronger than all previous until they’re the same size Force generated depends on: Frequency of stimulation Tuesday, March 24, 2015
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1. What could cause each twitch to be larger in magnitude if the tension is allowed to recover completely?
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