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Week%203%20solutions - MIMM 214 Solutions Set Week 3 Innate...

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MIMM 214 Solutions Set Week 3: Innate Immunity, Cytokines, and Antigen Presentation Which of the following cytokines is produced specifically during viral infection? a. IL-6 b. IFN- γ c. IL-12 d. TNF- α e. IL-4 Know your cytokines. IFN- γ is one of the key Th1 cytokines involved in a response to intracellular pathogens like viruses. Regarding NK cells, identify which of the following statements are true (you may select more than one choice). a. They require priming since they are of lymphoid lineage b. Release cytotoxic granules c. Are involved in killing tumor cells d. Recognize viral antigens to kill infected cells e. Generally act earlier than cytotoxic T-lymphocytes in the immune response NK cells do not require priming, unlike T-cells and B-cells, and target cells which are not expressing MHC Class I for death. Its cytotoxic activity does not involve direct recognition of viral antigens. What is pus composed of? Name a chemokine that could contribute to pus formation. Pus is a mixture of dead neutrophils, dead pathogens, and dead tissue. CXCL8 (IL-8) is an example of a chemokine that would contribute to pus formation, as its primary function is to recruit neutrophils to the site of injury. Which of the following would we not expect to see during a viral infection? a. IFN α and IFN β production b. Increased presentation on MHC class I c. Increased presentation on MHC class II d. Decreased expression of B7.1 and B7.2 (CD80 and CD86) e. NK cell activation CD80 and CD86 are costimulatory molecules that would be upregulated by APCs upon infection in order to increase activation of T-cells. Make a flowchart that places the following events in the correct order and list where each event occurs in the body. Some may occur at the same time. a. Complement activation b. T-cell activation and differentiation c. Recruitment of neutrophils to injured tissue d. TLR signalling e. Recruitment of T-cells to injured tissue f. Tissue injury
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g. Upregulation of costimulatory molecules h. Formation of memory lymphocytes The order goes as follows: f a, d c, g b e h Name a common feature of innate-like lymphocytes. They all cannot be boosted. Cytokines are both pleiotropic and redundant . What do these important properties mean when it comes to cytokine function? Choose the best answer: a. The same cytokine exerts the same effect on different tissues b.
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