MIMM214_ProblemsPackage - 1 Based on this picture of an...

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1. Based on this picture of an antibody, which of the following statements is FALSE? a. If the molecule is broken below the disulphide bonds no signalling can occur b. If the molecule is broken below the disulphide bonds antigen can be bound c. To use an antibody as a genetic tool to block the function of a specific molecule, we have to break the molecule at the disulfide bond an use only the top region d. If the disulfide bond between the light and heavy chain is broken, no antigen can be bound e. None of the above 2. What is not an implication of class switching? 3. Which of the following statements are false regarding CD4 and CD8 co-receptors? 4. What would you expect in a person who has a dysfunctional P56-Lck? 5. What is a correct statement concerning the relationship between CD28 and CTLA-4? a. CD28 and CTLA-4 both bind CD80 with greater affinity than CD86
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b. CD28 and CTLA both function to enhance T cell activation. c. CD28 activity is up-regulated upon T cell activation whereas CTLA-4 is constitutively active. d. CD28 and CTLA-4 are both co-stimulatory molecules. e. CD28 and CTLA-4 both function to inhibit B cell activation by sequestering B7. Answers: E, B, A
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  • Winter '12
  • J.Madrenas
  • following statements, T Cell, TCR, Heavy Chain, B cell

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