Anhydride Rxns - R 2 H 3 O i Organometallic Reagents e...

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CA DERIVATIVES ANHYDRIDE RXNS a) Hydrolysis R O O R OH O b) Alcoholysis R OR' O H 2 O Chemistry Specialist: Alicia Hart UC Davis - SASC c) Ammonolysis/Amminolysis R NH 2 O NH 3 - can use 1 and 2 amine, but NR with 3 amine d) Alkylation R R' OH 1. R'Li or R'MgX, Ether - given 2 eq. of the organometallic reagent, does alkylation twice by kicking off the carboxylate ion and reforming the carbonyl.
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Unformatted text preview: R' 2. H 3 O + i) Organometallic Reagents e) Reduction R H OH NaBH 4 , EtOH or 1. LiAlH 4 , ether 2. H 3 O + H R O (2) R O O R O R'OH R OH O R O O R O R OH O R OH O R O O R O R O O R O (2)...
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